TLC Bioautography-guided Isolation and Antimicrobial, Antifungal Effects of 12 Alkaloids from Hylomecon japonica Roots

被引：0
|
作者：
Xue, Xuanji [1 ]
Zhang, Hui [1 ]
Zhang, Xinxin [1 ]
Liu, Xia [1 ]
Xi, Ke [1 ]
Han, Yanxia [1 ]
Guo, Zengjun [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Pharm, 76 West Yanta Rd, Xian 710061, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 09期
关键词：
TLC bioautography-guided isolation; Antimicrobial and Antifungal effect; Hylomecon japonica; Alkaloids; ANTIBACTERIAL ACTIVITIES; CHEMICAL-COMPOSITION; ANTIOXIDANT; IDENTIFICATION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hylomecon japonica (Thunb.) Prantl. is a Chinese medicinal plant whose active components and their antimicrobial mechanism was studied by TLC bioautography-guided isolation and identification of 12 alkaloids and their antimicrobial activities evaluated using the standard broth microdilution method. The benzophenanthridine isoquinoline alkaloids showed the strongest inhibitory activity against Gram-positive bacteria. Analysis of conductivity changes and observation of TEM images revealed that the antimicrobial mechanism involved cell integrity damage and cell division arrest.
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页码：1439 / 1442
页数：4
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