A practical synthesis of α-amino ketones via aryllithium addition to N-boc-α-amino acids

被引：0

作者：

Florjancic, AS ^{[1
]}

Sheppard, GS ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Prod Res & Dev, Abbott Pk, IL 60064 USA

来源：

SYNTHESIS-STUTTGART | 2003年 / 11期

关键词：

arylations; amino acids; lithiation; ketones; nucleophilic additions;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of N-Boc-alpha-amino acids with aryllithium reagents followed by removal of the nitrogen protecting group provides enantiomerically pure alpha-amino aryl ketones as their corresponding HCl salts. This practical two-step sequence gives rapid access to a pharmaceutically interesting class of compounds from commercially available starting materials.

引用

页码：1653 / 1656

页数：4

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