MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites

被引：17
|
作者：
Hinshaw, Samuel J. [1 ]
Lee, Amy H. Y. [1 ]
Gill, Erin E. [1 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada
来源：
BIOINFORMATICS | 2018年 / 34卷 / 18期
关键词：
METABOLOMICS; TECHNOLOGIES; PATHWAYS;
D O I：
10.1093/bioinformatics/bty331
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
aSummary: Here, we present MetaBridge, a tool that collates protein interactors (curated metabolite-enzyme interactions) that influence the levels of specific metabolites including both biosynthetic and degradative enzymes. This enables network-based integrative analysis of metabolomics data with other omics data types. MetaBridge is designed to complement a systems-biology approach to analysis, pairing well with network analysis tools such as NetworkAnalyst.ca, but can be used in any bioinformatics workflow. Availability and implementation: MetaBridge has been implemented as a web tool at https://www.metabridge.org, and the source code is available at https://github.com/samhinshaw/metabridge_shiny (GNU GPLv3). Contact: bob@hancocklab.com
引用
收藏
页码：3225 / 3227
页数：3
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