Mechanisms of endocannabinoid control of synaptic plasticity

被引:31
|
作者
Winters, Bryony Laura [1 ]
Vaughan, Christopher Walter [1 ]
机构
[1] Univ Sydney, Royal North Shore Hosp, Northern Clin Sch, Kolling Inst Med Res,Pain Management Res Inst, Sydney, NSW, Australia
关键词
Cannabinoids; Endocannabinoids; Synaptic plasticity; LONG-TERM DEPRESSION; METABOTROPIC GLUTAMATE RECEPTORS; DIACYLGLYCEROL-LIPASE-ALPHA; TRANSPORT INHIBITOR AM404; CB1 CANNABINOID RECEPTOR; MEDIUM SPINY NEURONS; DEPOLARIZATION-INDUCED SUPPRESSION; TIMING-DEPENDENT PLASTICITY; PRESYNAPTIC CALCIUM INFLUX; RAT HIPPOCAMPAL-NEURONS;
D O I
10.1016/j.neuropharm.2021.108736
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The endogenous cannabinoid transmitter system regulates synaptic transmission throughout the nervous system. Unlike conventional transmitters, specific stimuli induce synthesis of endocannabinoids (eCBs) in the postsynaptic neuron, and these travel backwards to modulate presynaptic inputs. In doing so, eCBs can induce short-term changes in synaptic strength and longer-term plasticity. While this eCB regulation is near ubiquitous, it displays major regional and synapse specific variations with different synapse specific forms of short-versus long-term plasticity throughout the brain. These differences are due to the plethora of pre- and postsynaptic mechanisms which have been implicated in eCB signalling, the intricacies of which are only just being realised. In this review, we shall describe the current understanding and highlight new advances in this area, with a focus on the retrograde action of eCBs at CB1 receptors (CB(1)Rs). This article is part of the special Issue on 'Cannabinoids'.
引用
收藏
页数:23
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