Cancer after renal transplantation

被引:44
|
作者
Vasudev, Brahm [1 ]
Hariharan, Sundaram [1 ]
机构
[1] Med Coll Wisconsin, Div Nephrol, Milwaukee, WI 53226 USA
来源
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2007年 / 16卷 / 06期
关键词
cancer; immunosuppressants; renal transplant;
D O I
10.1097/MNH.0b013e3282f06bba
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Prolonged waiting times for renal transplantation, an increase in the average age of recipients, decreased acute rejection rates due to use of newer potent immunosuppressives and improving long-term transplant survival have raised concerns in the transplant community regarding posttransplant cancer. In view of the fact that transplant recipients are living longer, it is of paramount importance that we continue to translate discoveries at the bench to the bedside and document cancers in the posttransplant recipient registries. Analysis of data will help in optimizing patient management. Recent findings Recent evidence indicates that sirolimus is associated with a decreased incidence of posttransplant de-novo cancer and remission of Kaposi's sarcoma and nonmelanoma skin cancer. Mycophenolate mofetil has been shown to have an antiproliferative activity against leukemia and lymphoma and an anti-tumor effect against colon and prostate cancer. Clinically it has been shown to be associated with a reduced incidence of cancers like posttransplant lymphoproliferative disorder. Summary Appropriate selection of transplant candidates, pretranspant and posttransplant cancer surveillance and judicious evidence-based use of newer immunosuppressants may help reduce the incidence and improve the outcome of posttransplant cancer.
引用
收藏
页码:523 / 528
页数:6
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