Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

被引：18
|
作者：
Lin, Fu-Yang [1 ]
Zhang, Yonghui [2 ]
Hensler, Mary [3 ,4 ]
Liu, Yi-Liang [1 ]
Chow, Ohn A. [3 ,4 ]
Zhu, Wei [1 ]
Wang, Ke [2 ]
Pang, Ran [2 ]
Thienphrapa, Wdee [3 ,4 ]
Nizet, Victor [3 ,4 ]
Oldfield, Eric [1 ,2 ]
机构：
[1] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
[3] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
来源：
CHEMMEDCHEM | 2012年 / 7卷 / 04期
基金：
美国国家卫生研究院;
关键词：
immunology; isoprenoid biosynthesis; neutrophil extracellular traps; virulence factor; X-ray diffraction; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1002/cmdc.201100589
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：561 / 564
页数：4
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