A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo [1,2-b]Isoxazolyl-N-aryl Thiazol Amines

被引：1
|
作者：
Rajanarendar, E. [1 ]
Thirupathaiah, K. [1 ]
Ramakrishna, S. [1 ]
Nagaraju, D. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Telangana State, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 53卷 / 06期
关键词：
IN-VITRO; ANTICANCER ACTIVITY; PHASE SYNTHESIS; IONIC LIQUID; DERIVATIVES; INHIBITORS; AMINOTHIAZOLES; HETEROCYCLES; ISOXAZOLYL; DESIGN;
D O I：
10.1002/jhet.2518
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Hantzsch synthesis of novel aryl imidazo[1,2-b]isoxazolyl-N-aryl thiazol amines 5 analogues were described. Reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-arylimidazo[1,2-b]isoxazoles 3 in good yields. Compounds 3 on reaction with chloroacetyl chloride in 1,4-dioxane furnished the corresponding 2-chloro-1-(6-methyl-3-arylimidazo[1,2-b] isoxazol-2-yl)ethanones 4. Compounds 4 on heating with N-aryl thioureas in an oil bath underwent cyclization to afford the title compounds viz., imidazo[1,2-b] isoxazolyl-N-aryl thiazol amines 5 in moderate to good yields by Hantzsch synthesis.
引用
收藏
页码：1983 / 1989
页数：7
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