FREQUENCY AND CHARACTERISTICS OF INTRAOCULAR INFLAMMATION AFTER AFLIBERCEPT INJECTION

被引：20

作者：

Fine, Howard F. ^{[1
]}

Roth, Daniel B. ^{[1
]}

Shah, Sumit P. ^{[1
]}

Haque, Tahia ^{[1
]}

Wheatley, Matthew ^{[1
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, Dept Ophthalmol, New Brunswick, NJ 08901 USA

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2015年 / 35卷 / 04期

关键词：

aflibercept; endophthalmitis; intravitreal injection; noninfectious endophthalmitis; uveitis; INTRAVITREAL INJECTION; MACULAR DEGENERATION; RANIBIZUMAB INJECTIONS; BEVACIZUMAB; SAFETY; VERTEPORFIN;

D O I：

10.1097/IAE.0000000000000398

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report the frequency and characteristics of intraocular inflammation after intravitreal aflibercept injection. Methods: A single-center retrospective study was performed in patients who received intravitreal aflibercept from November 2011 through June 2013. Results: There were 28 cases of intraocular inflammation after a total of 5,905 aflibercept injections among 1,660 patients. The mean baseline acuity was 20/57, which decreased to 20/179 at diagnosis (P < 0.0001) but recovered to 20/59 at Month 1, 20/57 at Month 3, and 20/52 at Month 6 (P = not significant). Vitreous culture and injection of antibiotics were performed in eight cases, and all were culture negative; the remainder received only topical corticosteroids. Conclusion: The frequency of inflammation after aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroid treatment.

引用

页码：681 / 686

页数：6

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