Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp.

被引：9

作者：

Peng, Bo-Rong ^{[1
,2
,3
]}

Lai, Kuei-Hung ^{[4
]}

Chen, You-Ying ^{[3
,5
]}

Su, Jui-Hsin ^{[3
,6
]}

Huang, Yusheng M. ^{[7
]}

Chen, Yu-Hsin ^{[3
]}

Lu, Mei-Chin ^{[3
,6
]}

Yu, Steve Sheng-Fa ^{[2
,8
]}

Duh, Chang-Yih ^{[1
,5
]}

Sung, Ping-Jyun ^{[3
,5
,6
,9
,10
]}

机构：

[1] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

[2] Acad Sinica, Doctoral Degree Program Marine Biotechnol, Taipei 11529, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 94450, Taiwan

[4] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 33303, Taiwan

[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan

[6] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan

[7] Natl Penghu Univ Sci & Technol, Dept Marine Recreat, Magong 88046, Penghu, Taiwan

[8] Acad Sinica, Inst Chem, Taipei 11529, Taiwan

[9] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan

[10] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan

来源：

MARINE DRUGS | 2020年 / 18卷 / 02期

关键词：

scalarane; sesterterpenoid; anti-proliferation; Lendenfeldia; BISHOMOSCALARANE SESTERTERPENES; METABOLITES;

D O I：

10.3390/md18020076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A-D (1- 4), along with three known compounds, 12 alpha-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1-7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1-7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

引用

页数：10

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