Nineteen months into the pandemic, what have we learned about COVID-19-related outcomes in patients with psoriasis?

被引:4
|
作者
Kridin, Khalaf [1 ,2 ,3 ]
Schonmann, Yochai [4 ,5 ]
Onn, Erez [2 ,6 ]
Bitan, Dana Tzur [7 ,8 ]
Weinstein, Orly [4 ,5 ]
Shavit, Eran [9 ,10 ]
Cohen, Arnon D. [4 ,5 ]
机构
[1] Baruch Padeh Poria Med Ctr, Unit Dermatol & Skin Res Lab, Tiberias, Israel
[2] Bar Ilan Univ, Azrieli Fac Med, Safed, Israel
[3] Univ Lubeck, Lubeck Inst Expt Dermatol, Lubeck, Germany
[4] Cialit Hlth Serv, Tel Aviv, Israel
[5] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel
[6] Baruch Padeh Med Ctr, Poriya, Israel
[7] Ariel Univ, Dept Behav Sci, Ariel, Israel
[8] Tel Aviv Univ, Sackler Sch Med, Shalvata Mental Hlth Ctr, Ramat Aviv, Israel
[9] Wolfson Med Ctr, Dermatol Clin, Holon, Israel
[10] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
关键词
coronavirus disease 2019; COVID-19; psoriasis; SARS-CoV-2; infection; SKIN;
D O I
10.1111/jocd.15351
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The impact of psoriasis on the outcomes of Coronavirus disease 2019 (COVID-19) is yet to be precisely delineated. Objectives: To assess the risk of COVID-19, COVID-19-associated hospitalization, and mortality among patients with psoriasis as compared with age-, sex-, and ethnicitymatched control subjects. In addition, we aim to delineate determinants of COVID-19-associated hospitalization and mortality in patients with psoriasis. Methods: A population-based retrospective cohort study was performed to longitudinally follow patients with psoriasis and their matched controls with regard to COVID-19-related outcomes. The risk of COVID-19 infection, COVID-19-associated hospitalization, and mortality were assessed using uni- and multi-variable Cox regression analyses. Determinants of COVID-19-associated hospitalization and mortality were evaluated using multivariable logistic regression analysis. Results: The study population included 144304 patients with psoriasis and 144304 age- and sex-matched control individuals. Patients with psoriasis displayed a slightly elevated risk of SARS-CoV-2 infection (fully-adjusted HR, 1.05; 95% CI, 1.03-1.08; p <0.001). Relative to controls, patients with psoriasis had comparable multivariate risk of COVID-19-associated hospitalization (fully-adjusted HR, 1.08; 95% CI, 0.99-1.18; p = 0.065) and COVID-19-associated mortality (fully-adjusted HR, 0.88; 95% CI, 0.73-1,05; p = 0.162). When evaluating individuals hospitalized due to COVID-19, patients with psoriasis were more likely to have type-2 diabetes mellitus (adjusted OR, 1.24; 95% CI, 1.03-1.50; p = 0.027) and obesity (adjusted OR, 1.37; 95% CI, 1.13-1.65; p = 0.001) relative to controls. Conclusions: While patients with psoriasis are at a higher risk of contracting SARS-CoV-2 infection, they are not more susceptible to the complications of COVID-19.
引用
收藏
页码:6549 / 6553
页数:5
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