Antimicrobial resistance of Helicobacter pylori isolated from dental plaque specimens

Background: Helicobacter pylori strains isolated from dental plaque samples may harbor severe antimicrobial resistance. The present research was performed to assess the antimicrobial resistance pattern of H. pylori strains isolated from dental plaque samples of individuals referred to dental clinics. Methods: Forty-two H. pylori strains were isolated from dental plaque samples. Isolation was performed using routine instructions in a microaerophilic condition. Isolates were subjected to disk diffusion to assess their antimicrobial resistance. Results: H. pylori strains harbored the uppermost resistance rate toward ampicillin (88.09%), clarithromycin (83.33%), amoxicillin (76.19%), metronidazole (71.42%), and tetracycline (69.04%) antimicrobials. H. pylori isolates harbored the lowermost resistance rate toward spiramycin (23.80%), furazolidone (26.19%), and rifampin (28.57%) antimicrobials. All isolates (100%) harbored simultaneous resistance toward at least 3 different antimicrobial agents, while simultaneous prevalence of resistance toward more than 7 antimicrobial agents was 35.71%. Conclusion: Authorized spiramycin, furazolidone, and rifampin antimicrobial agents prescription can be a suitable choice for oral H. pylori.