A Gelatin-Based Hydrogel with β-Cyclodextrin Crosslinker for Controlled Drug Release

被引：0
|
作者：
Liu, C. D. [1 ]
Zhang, Z. X. [2 ]
Chan, V. M. H. [1 ]
Tan, M. J. [1 ]
Liu, X. [1 ]
Li, J. [1 ,2 ]
机构：
[1] Natl Univ Singapore, Fac Engn, Div Bioengn, 9 Engn Dr 1, Singapore 117576, Singapore
[2] Natl Univ Singapore, Inst Mat Res Engn, Singapore 117602, Singapore
来源：
5TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING, PTS 1 AND 2 | 2012年 / 37卷
关键词：
Gelatin hydrogel; beta-cyclodextrin crosslinker; Inclusion complex; Controlled drug release; Methotrexate (MTX); DELIVERY;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel gelatin hydrogel was prepared by using 1, 1'-carbonyldiimidazole (CM) activated beta-cyclodextrin (beta-CD) as crosslinker. The hydrogel was characterized by H NMR spectroscopy, in vitro degradation, MTT assay, drug loading/release study with anticancer drug of methotrexate (MTX). Degradation and drug loading/release properties of the hydrogel can be controlled by changing the crosslinker content. In vitro cytotoxicity test indicated nontoxicity of this material to L929 cells (mouse connective tissue fibroblast), showing that this new crosslinked gelatin hydrogel is biocompatible and can be used as a potential drug carrier in human body.
引用
收藏
页码：1090 / +
页数：2
相关论文
共 50 条
  • [21] Desferrioxamine release from gelatin-based systems
    Ulubayram, K
    Kiziltay, A
    Yilmaz, E
    Hasirci, N
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2005, 42 : 237 - 245
  • [22] Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering
    Gnavi, S.
    di Blasio, L.
    Tonda-Turo, C.
    Mancardi, A.
    Primo, L.
    Ciardelli, G.
    Gambarotta, G.
    Geuna, S.
    Perroteau, I.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017, 11 (02) : 459 - 470
  • [23] Cyclodextrin-based controlled drug release system
    Hirayama, F
    Uekama, K
    ADVANCED DRUG DELIVERY REVIEWS, 1999, 36 (01) : 125 - 141
  • [24] Drug delivery from gelatin-based systems
    Foox, Maytal
    Zilberman, Meital
    EXPERT OPINION ON DRUG DELIVERY, 2015, 12 (09) : 1547 - 1563
  • [25] Gelatin-Based Foamed and Non-foamed Hydrogels for Sorption and Controlled Release of Metoprolol
    Dehli, Friederike
    Poole, Hailey
    Stubenrauch, Cosima
    Southan, Alexander
    ACS APPLIED POLYMER MATERIALS, 2021, 3 (11) : 5674 - 5682
  • [26] Smart fertilizers: preparation and characterization of gelatin-based hydrogels for controlled release of MAP and AN fertilizers
    Pulat, M.
    Yoltay, N.
    AGROCHIMICA, 2016, 60 (04): : 249 - 261
  • [27] Synthesis and Characterization of a Nanoclay Reinforced Gelatin-Based Hybrid Hydrogel
    Sakr, Mahmoud A.
    Siddiqua, Sumi
    Shin, Su Ryon
    Kim, Keekyoung
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2025, 113 (01)
  • [28] Development and Characterization of a Gelatin-Based Photoactive Hydrogel for Biomedical Application
    Straksys, Antanas
    Abouhagger, Adei
    Kirsnyte-Snioke, Monika
    Kavleiskaja, Tatjana
    Stirke, Arunas
    Melo, Wanessa C. M. A.
    JOURNAL OF FUNCTIONAL BIOMATERIALS, 2025, 16 (02)
  • [29] Gelatin-based hydrogels and ferrogels as smart drug delivery systems: synthesis, characterization and drug release kinetics
    Sahbaz, Deniz Akin
    POLYMER BULLETIN, 2024, 81 (06) : 5215 - 5235
  • [30] Gelatin-based hydrogels and ferrogels as smart drug delivery systems: synthesis, characterization and drug release kinetics
    Deniz Akın Şahbaz
    Polymer Bulletin, 2024, 81 : 5215 - 5235
12345