Discovery of BKM120, a pan class I PI3 kinase inhibitor in phase I/II clinical trials

被引:0
|
作者
Burger, Matthew T. [1 ]
Pecchi, Sabina [1 ]
Wagman, Allan [1 ]
Ni, Zhi-Jie [1 ]
Knapp, Mark [1 ]
Atallah, Gordana [1 ]
Pfister, Keith [1 ]
Ng, Simon [1 ]
Smith, Aaron [1 ]
Pick, Teresa [1 ]
Frazier, Kelly [1 ]
Verhagen, Joelle [1 ]
Zhang, Yanchen [1 ]
Bartulis, Sarah [1 ]
Hendricksen, Tom [1 ]
Iwanowicz, Edwin [1 ]
Hazenadar, Joshua [1 ]
Huh, Kay [1 ]
Ashash, Ahmad [1 ]
Xin, Xiaohua [1 ]
Menezes, Daniel [1 ]
Merritt, Hanne [1 ]
Wiesmann, Marion [1 ]
Voliva, Charles [1 ]
机构
[1] Novartis Inst Biomed Res, Emeryville, CA USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
489-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Phase 2 study of the pan-isoform PI3 kinase inhibitor BKM120 in metastatic urothelial carcinoma patients.
    Iyer, Gopa
    Tully, Christopher Michael
    Garcia-Grossman, Ilana Rebecca
    Scott, Sasinya N.
    Boyd, Mariel Elena
    Mccoy, Asia S.
    Berger, Michael F.
    Al-Ahmadie, Hikmat
    Solit, David B.
    Rosenberg, Jonathan E.
    Bajorin, Dean F.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (07)
  • [2] Phase I Safety Experience with the Oral Pan-class I PI3K Inhibitor BKM120 in Patients with Metastatic Breast Cancer (mBC)
    Saura, C.
    Burris, H.
    Arteaga, C. L.
    Mayer, I.
    Germa, C.
    Fretault, N.
    Sternberg, D.
    Trandafir, L.
    Massacesi, C.
    Rodon, J.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S96 - S96
  • [3] Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
    Bendell, Johanna C.
    Rodon, Jordi
    Burris, Howard A.
    de Jonge, Maja
    Verweij, Jaap
    Birle, Diana
    Demanse, David
    De Buck, Stefan S.
    Ru, Qinhua C.
    Peters, Malte
    Goldbrunner, Michael
    Baselga, Jose
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (03) : 282 - 290
  • [4] Phase II trial of the PI3 kinase inhibitor BKM120 with or without enzalutamide in men with metastatic castration resistant prostate cancer (mCRPC).
    Armstrong, Andrew J.
    Halabi, Susan
    Healy, Patrick
    Alumkal, Joshi J.
    Yu, Evan Y.
    Winters, Carolyn
    Hobbs, Carey
    Soleau, Colleen
    Slottke, Rachel
    Mundy, Kelly
    George, Daniel J.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [5] THE PAN-CLASS I PI3 KINASE INHIBITOR, NVP-BKM120, DEMONSTRATES ANTI-LEUKEMIC ACTIVITY IN ACUTE MYELOID LEUKEMIA
    Allegretti, M.
    Ricciardi, M. R.
    Licchetta, R.
    Mirabilii, S.
    Orecchioni, S.
    Reggiani, F.
    Talarico, G.
    Foa, R.
    Bertolini, F.
    Amadori, S.
    Tafuri, A.
    HAEMATOLOGICA, 2015, 100 : 211 - 211
  • [6] A first-in-human phase I study of BKM120, an oral pan-class I PI3K inhibitor, in patients (pts) with advanced solid tumors
    Baselga, J.
    De Jonge, M. J.
    Rodon, J.
    Burris, H. A., III
    Birle, D. C.
    De Buck, S. S.
    Demanse, D.
    Ru, Q. C.
    Goldbrunner, M.
    Bendell, J. C.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
  • [7] Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
    Burger, Matthew T.
    Pecchi, Sabina
    Wagman, Allan
    Ni, Zhi-Jie
    Knapp, Mark
    Hendrickson, Thomas
    Atallah, Gordana
    Pfister, Keith
    Zhang, Yanchen
    Bartulis, Sarah
    Frazier, Kelly
    Ng, Simon
    Smith, Aaron
    Verhagen, Joelle
    Haznedar, Joshua
    Huh, Kay
    Iwanowicz, Ed
    Xin, Xiaohua
    Menezes, Daniel
    Merritt, Hanne
    Lee, Isabelle
    Wiesmann, Marion
    Kaufman, Susan
    Crawford, Kenneth
    Chin, Michael
    Bussiere, Dirksen
    Shoemaker, Kevin
    Zaror, Isabel
    Maira, Sauveur-Michel
    Voliva, Charles F.
    ACS MEDICINAL CHEMISTRY LETTERS, 2011, 2 (10): : 774 - 779
  • [8] Phase I dose- escalation study of buparlisib ( BKM120), an oral pan- class I PI3K inhibitor, in Japanese patients with advanced solid tumors
    Ando, Yuichi
    Inada-Inoue, Megumi
    Mitsuma, Ayako
    Yoshino, Takayuki
    Ohtsu, Atsushi
    Suenaga, Naoko
    Sato, Masahiko
    Kakizume, Tomoyuki
    Robson, Matthew
    Quadt, Cornelia
    Doi, Toshihiko
    CANCER SCIENCE, 2014, 105 (03) : 347 - 353
  • [9] Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
    Rodon, Jordi
    Brana, Irene
    Siu, Lillian L.
    De Jonge, Maja J.
    Homji, Natasha
    Mills, David
    Di Tomaso, Emmanuelle
    Sarr, Celine
    Trandafir, Lucia
    Massacesi, Cristian
    Eskens, Ferry
    Bendell, Johanna C.
    INVESTIGATIONAL NEW DRUGS, 2014, 32 (04) : 670 - 681
  • [10] Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
    Jordi Rodon
    Irene Braña
    Lillian L Siu
    Maja J De Jonge
    Natasha Homji
    David Mills
    Emmanuelle Di Tomaso
    Celine Sarr
    Lucia Trandafir
    Cristian Massacesi
    Ferry Eskens
    Johanna C Bendell
    Investigational New Drugs, 2014, 32 : 670 - 681