Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives

被引：6

作者：

Zou, Hong-Bin ^{[1
,2
]}

Zhang, Liang ^{[1
]}

Yang, Lei-Xiang ^{[1
]}

Yang, Liu-Qing ^{[1
,2
]}

Zhao, Yu ^{[1
]}

Yu, Yong-Ping ^{[1
]}

Stoeckigt, Joachim ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Inst Mat Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Johannes Gutenberg Univ Mainz, Lehrstuhl Pharmazeut Biol, Inst Pharm, D-55099 Mainz, Germany

来源：

NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 03期

关键词：

cinnamic alcohol derivatives; cytotoxicity; structure-activity relationship; SINAPYL ALCOHOL; SYRINGIN;

D O I：

10.1080/14786410902830175

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three series of di- and trisubstituted derivatives of cinnamic alcohol and its conjugated dienol analogues were designed and synthesised. The derivatives were screened for cytotoxicity against nine tumour cell lines: KB, A549, Hela, CNE, PC-3, BEL-7404, HL-60, BGC823 and P388D1. Most of the cinnamic alcohol derivatives showed cytotoxic activity. The compound 7-(4',5'-dichlorobenzyloxy)-6,8-dihydroxycinnamic alcohol (55) exhibited significant cytotoxicity to seven human tumour cell lines on a micromolar range, especially with regard to the KB and P388D1 cell lines, showing IC50 values of 0.4 and 0.5 mu M, respectively. The structure-activity relationships of the derivatives are discussed.

引用

页码：203 / 221

页数：19

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