A Red Emissive Fluorescent Turn-on Sensor for the Rapid Detection of Selenocysteine and Its Application in Living Cells Imaging

被引：11

作者：

Wang, Zongcheng ^{[1
,2
]}

Zheng, Huihuang ^{[2
]}

Zhang, Chengliang ^{[1
]}

Tang, Dongfang ^{[2
]}

Wu, Qiyao ^{[1
]}

Dessie, Wubliker ^{[2
]}

Jiang, Yuren ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Hunan Univ Sci & Engn, Coll Chem & Biol Engn, Yongzhou 425199, Peoples R China

来源：

SENSORS | 2020年 / 20卷 / 17期

基金：

中国国家自然科学基金;

关键词：

fluorescent sensor; selenocysteine; long-wavelength; living cell fluorescence imaging; SELENIUM; PROBE; TISSUES;

D O I：

10.3390/s20174768

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The content of selenocysteine in cells has an important effect on a variety of human diseases, and the detection of selenocysteine by fluorescent sensors in vivo has shown many advantages. In order to further develop fast-reaction-time, good-selectivity, and high-sensitivity long-wavelength selenocysteine fluorescent sensors, we designed and synthesized the compoundYZ-A4as a turn-on fluorescent sensor to detect the content of selenocysteine. The quantitative detection range of the sensorYZ-A4to selenocysteine was from 0 to 32 mu M, and the detection limit was as low as 11.2 nM. The sensor displayed a rapid turn-on response, good selectivity, and high sensitivity to selenocysteine. Finally, we have demonstrated thatYZ-A4could be used for fluorescence imaging of selenocysteine in living cells.

引用

页码：1 / 10

页数：10

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