A Red Emissive Fluorescent Turn-on Sensor for the Rapid Detection of Selenocysteine and Its Application in Living Cells Imaging

被引：11
|
作者：
Wang, Zongcheng [1 ,2 ]
Zheng, Huihuang [2 ]
Zhang, Chengliang [1 ]
Tang, Dongfang [2 ]
Wu, Qiyao [1 ]
Dessie, Wubliker [2 ]
Jiang, Yuren [1 ]
机构：
[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
[2] Hunan Univ Sci & Engn, Coll Chem & Biol Engn, Yongzhou 425199, Peoples R China
来源：
SENSORS | 2020年 / 20卷 / 17期
基金：
中国国家自然科学基金;
关键词：
fluorescent sensor; selenocysteine; long-wavelength; living cell fluorescence imaging; SELENIUM; PROBE; TISSUES;
D O I：
10.3390/s20174768
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The content of selenocysteine in cells has an important effect on a variety of human diseases, and the detection of selenocysteine by fluorescent sensors in vivo has shown many advantages. In order to further develop fast-reaction-time, good-selectivity, and high-sensitivity long-wavelength selenocysteine fluorescent sensors, we designed and synthesized the compoundYZ-A4as a turn-on fluorescent sensor to detect the content of selenocysteine. The quantitative detection range of the sensorYZ-A4to selenocysteine was from 0 to 32 mu M, and the detection limit was as low as 11.2 nM. The sensor displayed a rapid turn-on response, good selectivity, and high sensitivity to selenocysteine. Finally, we have demonstrated thatYZ-A4could be used for fluorescence imaging of selenocysteine in living cells.
引用
收藏
页码：1 / 10
页数：10
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