Selective O-Difluoromethylation of 1,3-Diones by Bromodifluoromethylating Reagents

被引：53

作者：

Liu, Guokai ^{[1
]}

Wang, Xin ^{[1
]}

Xu, Xiu-Hua ^{[1
]}

Lu, Xu ^{[1
]}

Tokunaga, Etsuko ^{[1
]}

Tsuzuki, Seiji

Shibata, Norio ^{[1
]}

机构：

[1] Nagoya Inst Technol, Dept Frontier Mat, Grad Sch Engn, Showa Ku, Nagoya, Aichi, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 05期

关键词：

PHENYL SULFONE; EFFICIENT SYNTHESIS; TRIFLUOROMETHYLATION; DIFLUOROCARBENE; FACILE; (PHENYLSULFONYL)DIFLUOROMETHYLATION; FLUOROALKYLATION; ROUTE; SALTS; ACID;

D O I：

10.1021/ol4000313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective Odifluoromethylation of 1,3-diones was achieved via in situ generation of difluorocarbene from bromodifluoromethylating reagents in the presence of an organic base. A wide variety of difluormethyl enol ethers were obtained in good to excellent yields. The reaction mechanism is discussed based on ab initio calculations (kcal/mol).

引用

页码：1044 / 1047

页数：4

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