A simple way of recycling of homogeneous catalyst in Suzuki reaction

被引:5
|
作者
Manjunatha, Sulur G. [1 ]
Rangappa, Paramashivappa [1 ]
Sythana, Sureshkumar [1 ]
Babu, Sureshbabu M. [1 ]
Tadiparthi, Krishnaji [1 ]
Gundala, Chennakrishnareddy [1 ]
机构
[1] AstraZeneca India Pvt Ltd, Pharmaceut Dev, Bangalore 560024, Karnataka, India
关键词
homogeneous catalyst; catalyst recycling; Suzuki reaction; Pd-100; Pd-106; Pd-118; CROSS-COUPLING REACTIONS; ARYL CHLORIDES; PALLADIUM; SONOGASHIRA; MIYAURA; HALIDES; HECK;
D O I
10.1080/17518253.2012.705896
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple and practical method of recycling homogeneous catalysts in the Suzuki reaction using appropriate work up conditions is reported here. The commonly used and commercially available homogeneous catalysts 1 (Pd-100) dichlorobis(tri-phenylphosphine)palladium(II), 2 (Pd-106) dichloro[1,1-bis(diphenylphosphino)ferrocene]palladium(II)-dichloromethane adduct, and 3 (Pd-118) 1,1-bis(di-tert-butylphosphino)ferrocene]dichloropalladium(II) selected for our study and were recycled successfully for three times using simple acidic and basic work up conditions depending on the presence of amino or carboxylic acid functional group in the product.
引用
收藏
页码:77 / 87
页数:11
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