Molecular Mechanisms of Viral Immune Evasion Proteins to Inhibit MHC Class I Antigen Processing and Presentation

被引：13

作者：

Zhou, Fang ^{[1
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld 4102, Australia

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2009年 / 28卷 / 05期

关键词：

viral immune evasion protein; MHC class I antigen presentation; IFN-gamma; JAK/STAT signal transduction pathway; CTL epitope; IRF-1; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDE-LOADING COMPLEX; UBIQUITIN-CONJUGATING ENZYME; INTERFERON REGULATORY FACTOR; SIMPLEX-VIRUS TYPE-1; TRANS-GOLGI NETWORK; DOUBLE-STRANDED-RNA; INFLUENZA-B VIRUS; CELL-CYCLE ARREST; KINASE PKR;

D O I：

10.1080/08830180903013034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral products inhibit MHC class I antigen processing and presentation via three major pathways: inhibition of major histocompatibility complex WHO class I expression on cells, blockade of peptide trafficking and loading on MHC class I molecules, and inhibition of peptide generation in host cells. Viral products also interfere with IFN-gamma-mediated JAK/STAT signal transduction in cells. These results imply that viral proteins probably inhibit the function of IFN-gamma in MHC class I antigen presentation via inactivation of JAK/STAT signal transduction in host cells. Mechanisms of viral products to inhibit IFN-gamma-mediated MHC class I antigen presentation were summarized in this literature review.

引用

页码：376 / 393

页数：18

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