Caenorhabditis elegans reveals novel Pseudomonas aeruginosa virulence mechanism

被引:26
|
作者
Utari, Putri Dwi [1 ]
Quax, Wim J. [1 ]
机构
[1] Univ Groningen, Dept Pharmaceut Biol, NL-9713 AV Groningen, Netherlands
关键词
PAO1;
D O I
10.1016/j.tim.2013.04.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performing high-throughput screens for novel antibiotics using a whole-body infection system.
引用
收藏
页码:315 / 316
页数:2
相关论文
共 50 条
  • [1] The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans
    Vasquez-Rifo, Alejandro
    Veksler-Lublinsky, Isana
    Cheng, Zhenyu
    Ausubel, Frederick M.
    Ambros, Victor
    GENOME BIOLOGY, 2019, 20 (01)
  • [2] Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system
    Adonizio, Allison
    Leal, Sixto M., Jr.
    Ausubel, Frederick M.
    Mathee, Kalai
    JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (07) : 809 - 813
  • [3] The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans
    Alejandro Vasquez-Rifo
    Isana Veksler-Lublinsky
    Zhenyu Cheng
    Frederick M. Ausubel
    Victor Ambros
    Genome Biology, 20
  • [4] Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P-aeruginosa virulence factors
    Tan, MW
    Rahme, LG
    Sternberg, JA
    Tompkins, RG
    Ausubel, FM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) : 2408 - 2413
  • [5] Disarming Pseudomonas aeruginosa Virulence Factor LasB by Leveraging a Caenorhabditis elegans Infection Model
    Zhu, Jie
    Cai, Xiaoqing
    Harris, Tyler L.
    Gooyit, Major
    Wood, Malcolm
    Lardy, Matthew
    Janda, Kim D.
    CHEMISTRY & BIOLOGY, 2015, 22 (04): : 483 - 491
  • [6] Feeding behaviour of Caenorhabditis elegans is an indicator of Pseudomonas aeruginosa PAO1 virulence
    Lewenza, Shawn
    Charron-Mazenod, Laetitia
    Giroux, Lauriane
    Zamponi, Alexandra D.
    PEERJ, 2014, 2
  • [7] Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa
    Darby, C
    Cosma, CL
    Thomas, JH
    Manoil, C
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 15202 - 15207
  • [8] A Novel Metagenomic Short-Chain Dehydrogenase/Reductase Attenuates Pseudomonas aeruginosa Biofilm Formation and Virulence on Caenorhabditis elegans
    Bijtenhoorn, Patrick
    Mayerhofer, Hubert
    Mueller-Dieckmann, Jochen
    Utpatel, Christian
    Schipper, Christina
    Hornung, Claudia
    Szesny, Matthias
    Grond, Stephanie
    Thuermer, Andrea
    Brzuszkiewicz, Elzbieta
    Daniel, Rolf
    Dierking, Katja
    Schulenburg, Hinrich
    Streit, Wolfgang R.
    PLOS ONE, 2011, 6 (10):
  • [9] Quorum-Quenching Acylase Reduces the Virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans Infection Model
    Papaioannou, Evelina
    Wahjudi, Mariana
    Nadal-Jimenez, Pol
    Koch, Gudrun
    Setroikromo, Rita
    Quax, Wim J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (11) : 4891 - 4897
  • [10] Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa Caenorhabditis elegans pathogenesis model
    Mahajan-Miklos, S
    Tan, MW
    Rahme, LG
    Ausubel, FM
    CELL, 1999, 96 (01) : 47 - 56