Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise

被引:14
|
作者
Herrenbruck, Adrienne R. [1 ]
Bollinger, Lance M. [1 ]
机构
[1] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY USA
关键词
INSULIN-RESISTANCE; UBIQUITIN; MITOCHONDRIA; DEGRADATION; MITOPHAGY; ULK1; DYSFUNCTION; BIOGENESIS; ADAPTATION; STARVATION;
D O I
10.1093/nutrit/nuz044
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.
引用
收藏
页码:56 / 64
页数:9
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