Performance of the GeneXpert CT/NG Assay Compared to That of the Aptima AC2 Assay for Detection of Rectal Chlamydia trachomatis and Neisseria gonorrhoeae by Use of Residual Aptima Samples

被引：38
|
作者：
Goldenberg, S. D. [1 ,2 ]
Finn, J.
Sedudzi, E. [3 ]
White, J. A. [4 ]
Tong, C. Y. W. [1 ,2 ]
机构：
[1] Guys & St Thomas NHS Fdn Trust, Ctr Clin Infect & Diagnost Res, London, England
[2] Kings Coll London, London WC2R 2LS, England
[3] GSTS Pathol, London, England
[4] Guys & St Thomas NHS Fdn Trust, Dept Genitourinary Med, London, England
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 12期
关键词：
DIAGNOSIS; SWABS; MEN; SEX;
D O I：
10.1128/JCM.01930-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
There are currently no commercially available molecular assays for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in rectal swabs with regulatory approval. We compared the Cepheid GeneXpert CT/NG assay with the GenProbe Aptima Combo2 assay, using 409 rectal swabs. Using Aptima as the gold standard, the sensitivity, specificity, and positive and negative predictive values of GeneXpert for the detection of C. trachomatis and N. gonorrhoeae were 86%, 99.2%, 92.5%, and 98.4% and 91.1%, 100%, 100%, and 98.6%, respectively. Despite significant dilution of samples prior to GeneXpert testing, the assay performed well with excellent specificity.
引用
收藏
页码：3867 / 3869
页数：3
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