Optimization of cooling strategy and seeding by FBRM analysis of batch crystallization

被引：29

作者：

Zhang, Dejiang ^{[1
,2
]}

Liu, Lande ^{[3
]}

Xu, Shijie ^{[1
,2
]}

Du, Shichao ^{[1
,2
]}

Dong, Weibing ^{[1
,2
]}

Gong, Junbo ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China

[3] Univ Huddersfield, Sch Appl Sci, Huddersfield HD1 3DH, W Yorkshire, England

来源：

JOURNAL OF CRYSTAL GROWTH | 2018年 / 486卷

基金：

中国国家自然科学基金;

关键词：

Batch crystallization; Constant growth rate trajectory; FBRM; Optimized seed policy; Optimization; CRYSTAL SIZE DISTRIBUTION; DIRECT NUCLEATION CONTROL; DESIGN; DISTRIBUTIONS; PERSPECTIVE; ZONE;

D O I：

10.1016/j.jcrysgro.2017.12.046

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

A method is presented for optimizing the cooling strategy and seed loading simultaneously. Focused beam reflectance measurement (FBRM) was used to determine the approximating optimal cooling profile. Using these results in conjunction with constant growth rate assumption, modified Mullin-Nyvlt trajectory could be calculated. This trajectory could suppress secondary nucleation and has the potential to control product's polymorph distribution. Comparing with linear and two step cooling, modified Mullin-Nyvlt trajectory have a larger size distribution and a better morphology. Based on the calculating results, the optimized seed loading policy was also developed. This policy could be useful for guiding the batch crystallization process. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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