CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes

被引：40
|
作者：
Catalano, Myriam [1 ,2 ]
Lauro, Clotilde [1 ]
Cipriani, Raffaela [1 ]
Chece, Giuseppina [1 ]
Ponzetta, Andrea [1 ]
Di Angelantonio, Silvia [1 ,3 ]
Ragozzino, Davide [1 ,2 ]
Limatola, Cristina [1 ,2 ]
机构：
[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Fdn Cenci Bolognetti, I-00185 Rome, Italy
[2] IRCCS Neuromed, I-86077 Pozzilli, Italy
[3] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, Rome, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 263卷 / 1-2期
关键词：
CX3CL1; Neuroprotection; GLT-1; Astrocytes; Microglia; A1R; SENSITIVE EAAT2 EXPRESSION; FOCAL CEREBRAL-ISCHEMIA; GLUTAMATE UPTAKE; FRACTALKINE-RECEPTOR; CULTURED ASTROCYTES; HIPPOCAMPAL-NEURONS; DOWN-REGULATION; ADENOSINE; NEUROPROTECTION; TRANSPORTERS;
D O I：
10.1016/j.jneuroim.2013.07.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 increases GLT-1 activity on astrocytes. The modulation of GLT-1 activity induced by CX3CL1 on astrocytes requires the presence and the activity of A1 adenosine receptor (A(1)R), being blocked by the specific antagonist DPCPX and absent in A(1)R(-/-) astrocytes. These data introduce the astrocytes as active players in CX3CL1-mediated signaling between microglia and neurons, identifying GLT-1 as a key mediator of the neuroprotective activity of CX3CL1. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：75 / 82
页数：8
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