CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes

被引：40

作者：

Catalano, Myriam ^{[1
,2
]}

Lauro, Clotilde ^{[1
]}

Cipriani, Raffaela ^{[1
]}

Chece, Giuseppina ^{[1
]}

Ponzetta, Andrea ^{[1
]}

Di Angelantonio, Silvia ^{[1
,3
]}

Ragozzino, Davide ^{[1
,2
]}

Limatola, Cristina ^{[1
,2
]}

机构：

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Fdn Cenci Bolognetti, I-00185 Rome, Italy

[2] IRCCS Neuromed, I-86077 Pozzilli, Italy

[3] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, Rome, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 263卷 / 1-2期

关键词：

CX3CL1; Neuroprotection; GLT-1; Astrocytes; Microglia; A1R; SENSITIVE EAAT2 EXPRESSION; FOCAL CEREBRAL-ISCHEMIA; GLUTAMATE UPTAKE; FRACTALKINE-RECEPTOR; CULTURED ASTROCYTES; HIPPOCAMPAL-NEURONS; DOWN-REGULATION; ADENOSINE; NEUROPROTECTION; TRANSPORTERS;

D O I：

10.1016/j.jneuroim.2013.07.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 increases GLT-1 activity on astrocytes. The modulation of GLT-1 activity induced by CX3CL1 on astrocytes requires the presence and the activity of A1 adenosine receptor (A(1)R), being blocked by the specific antagonist DPCPX and absent in A(1)R(-/-) astrocytes. These data introduce the astrocytes as active players in CX3CL1-mediated signaling between microglia and neurons, identifying GLT-1 as a key mediator of the neuroprotective activity of CX3CL1. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：75 / 82

页数：8

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