The Mre11 nuclease is critical for sensitivity of cells to Chk1 inhibition

被引：0
|
作者：
Thompson, Ruth H. [1 ]
Montano, Ryan E. [1 ]
Eastman, Alan R. [1 ]
机构：
[1] Dartmouth Coll, Hanover, NH 03755 USA
来源：
CANCER RESEARCH | 2012年 / 72卷
关键词：
D O I：
10.1158/1538-7445.AM2012-2040
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2040
引用
收藏
页数：1
相关论文
共 50 条
  • [11] Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy
    Massey, Andrew J.
    CANCER LETTERS, 2016, 383 (01) : 41 - 52
  • [12] Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity
    Andrew J. Massey
    Scientific Reports, 6
  • [13] mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells
    Koppenhafer, Stacia L.
    Goss, Kelli L.
    Terry, William W.
    Gordon, David J.
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (12) : 2676 - 2688
  • [14] Exploring the effects of PARP inhibition on CHK1 activation as a potential determinant of synergy with CHK1 inhibition.
    Wielgos-Bonvallet, Monicka
    Cybulska, Paulina
    Van Oudenhove, Elke
    Jelinic, Petar
    Levine, Douglas A.
    CLINICAL CANCER RESEARCH, 2018, 24 (15) : 28 - +
  • [15] Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast
    Arora, Sucheta
    Deshpande, Rajashree A.
    Budd, Martin
    Campbell, Judy
    Revere, America
    Zhang, Xiaoming
    Schmidt, Kristina H.
    Paull, Tanya T.
    MOLECULAR AND CELLULAR BIOLOGY, 2017, 37 (24)
  • [16] Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions
    Rahman, Samiur
    Beikzadeh, Mahtab
    Canny, Marella D.
    Kaur, Navneet
    Latham, Michael P.
    JOURNAL OF MOLECULAR BIOLOGY, 2020, 432 (10) : 3289 - 3308
  • [17] Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1
    Duan, Lei
    Perez, Ricardo E.
    Hansen, Michael
    Gitelis, Steven
    Maki, Carl G.
    CANCER BIOLOGY & THERAPY, 2014, 15 (12) : 1600 - 1612
  • [18] Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity
    Massey, Andrew J.
    SCIENTIFIC REPORTS, 2016, 6
  • [19] Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition
    Venkatesha, Venkatasubbaiah A.
    Parsels, Leslie A.
    Parsels, Joshua D.
    Zabludoff, Sonya D.
    Maybaum, Jonathan
    Lawrence, Theodore S.
    Morgan, Meredith A.
    CANCER RESEARCH, 2011, 71
  • [20] Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition
    Venkatesha, Venkatasubbaiah A.
    Parsels, Leslie A.
    Parsels, Joshua D.
    Zhao, Lili
    Zabludoff, Sonya D.
    Simeone, Diane M.
    Maybaum, Jonathan
    Lawrence, Theodore S.
    Morgan, Meredith A.
    NEOPLASIA, 2012, 14 (06): : 519 - 525
12345