Prevention of peroxynitrite-induced oxidation and nitration reactions by ellagic acid

被引：12
|
作者：
Ippoushi, Katsunari [1 ]
Takeuchi, Atsuko [1 ]
Azuma, Keiko [1 ]
机构：
[1] Natl Agr & Food Res Org, Natl Inst Vegetable & Tea Sci, Tsu, Mie 5142392, Japan
来源：
FOOD CHEMISTRY | 2009年 / 112卷 / 01期
关键词：
ellagic acid; peroxynitrite; antioxidative effect; IN-VITRO; TYROSINE NITRATION; DNA-DAMAGE; INHIBITION; NITROGEN; SYSTEM; IMPACT;
D O I：
10.1016/j.foodchem.2008.05.057
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Four benzoic acid derivatives and three phenylpropanoids were tested for their ability to suppress oxidation of dichlorodihydrofluorescein (DCDHF) induced by 3-morpholinosydnonimine (SIN-1, a peroxynitrite donor). Ellagic acid was found to potently inhibit this oxidation and to inhibit oxidation of DCDHF induced by peroxynitrite itself. Moreover, this compound prevented peroxynitrite-induced oxidative single strand breaks in pTZ 18U plasmid DNA and nitration of tyrosyl residues in bovine serum albumin. These results show that ellagic acid protects biomolecules against oxidative and nitrative damage induced by peroxynitrite in vitro. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：185 / 188
页数：4
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