Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells

Chlorogenic acid (CGA) is one of the most abundant polyphenols in the human diet and has various biological properties such as antimicrobial and antioxidant activities. Although the biophysiological effects of CGA are well studied, its effect on stem cell differentiation has not been observed until recently. In this study, it was demonstrated that CGA promotes osteogenesis in human adipose tissue-derived mesenchymal stem cells (hAMSCs), as indicated by increased mineralization. The mRNA levels of alkaline phosphatase and runt-related transcription factor 2 increased significantly following treatment with 30 mu M CGA. These results suggest a novel effect of CGA on osteogenic differentiation in hAMSCs and the possibility that CGA might affect the differentiation of other types of stem cells.