Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?

被引:65
|
作者
Cordero, Mario D. [1 ]
Alcocer-Gomez, Elisabet [1 ]
de Miguel, Manuel [1 ]
Culic, Ognjen [2 ]
Carrion, Angel M. [3 ]
Miguel Alvarez-Suarez, Jose [4 ]
Bullon, Pedro [5 ]
Battino, Maurizio [4 ]
Fernandez-Rodriguez, Ana [1 ]
Antonio Sanchez-Alcazar, Jose [6 ,7 ]
机构
[1] Univ Seville, Dpto Citol & Histol Normal & Patol, Fac Med, E-41009 Seville, Spain
[2] Univ Zagreb, Fac Pharm & Biochem, Zagreb 41000, Croatia
[3] Univ Pablo de Olavide Sevilla, Div Neurociencias, Seville, Spain
[4] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Ancona, Italy
[5] Univ Seville, Dept Periodontol, Fac Odontol, E-41009 Seville, Spain
[6] Univ Pablo de Olavide CSIC Junta Andalucia, CABD, Seville, Spain
[7] ISCIII, Ctr Invest Biomed Red Enfermedades Rares CIBERER, Seville, Spain
关键词
AMPK;
D O I
10.1089/ars.2013.5260
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q(10) (CoQ(10)) deficiency have been implicated in FM pathophysiology. We have investigated the effect of CoQ(10) supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ(10) supplementation (300mg/day) on 20 FM patients. This study was registered with controlled-trials.com (ISRCTN 21164124). An important clinical improvement was evident after CoQ(10)versus placebo treatment showing a reduction of FIQ (p<0.001), and a most prominent reduction in pain (p<0.001), fatigue, and morning tiredness (p<0.01) subscales from FIQ. Furthermore, we observed an important reduction in the pain visual scale (p<0.01) and a reduction in tender points (p<0.01), including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis, and AMPK gene expression levels, associated with phosphorylation of the AMPK activity. These results lead to the hypothesis that CoQ(10) have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM. Antioxid. Redox Signal. 19, 1356-1361.
引用
收藏
页码:1356 / 1361
页数:6
相关论文
共 50 条
  • [41] Pharmacokinetics of coenzyme Q10
    E. I. Kalenikova
    E. A. Gorodetskaya
    O. S. Medvedev
    Bulletin of Experimental Biology and Medicine, 2008, 146 : 313 - 316
  • [42] Coenzyme Q10 Deficiency
    Kiesewetter, Holger
    DEUTSCHES ARZTEBLATT INTERNATIONAL, 2016, 113 (19): : 344 - 345
  • [43] The Use of the Coenzyme Q10 as a Food Supplement in the Management of Fibromyalgia: A Critical Review
    Campisi, Luca
    La Motta, Concettina
    ANTIOXIDANTS, 2022, 11 (10)
  • [44] Atherosclerosis and Coenzyme Q10
    Suarez-Rivero, Juan M.
    Pastor-Maldonado, Carmen J.
    de la Mata, Mario
    Villanueva-Paz, Marina
    Povea-Cabello, Suleva
    Alvarez-Cordoba, Monica
    Villalon-Garcia, Irene
    Suarez-Carrillo, Alejandra
    Talaveron-Rey, Marta
    Munuera, Manuel
    Sanchez-Alcazar, Jose A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (20)
  • [45] Pharmacokinetics of Coenzyme Q10
    Kalenikova, E. I.
    Gorodetskaya, E. A.
    Medvedev, O. S.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (03) : 313 - 316
  • [46] Statins and coenzyme Q10
    Ellis, CJ
    Scott, R
    LANCET, 2003, 361 (9363): : 1134 - 1135
  • [47] NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10
    Cordero, Mario D.
    Alcocer-Gomez, Elisabet
    Culic, Ognjen
    Carrion, Angel M.
    de Miguel, Manuel
    Diaz-Parrado, Eduardo
    Perez-Villegas, Eva M.
    Bullon, Pedro
    Battino, Maurizio
    Antonio Sanchez-Alcazar, Jose
    ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (08) : 1169 - 1180
  • [48] The Synthesis of Coenzyme Q10
    Luo, Meng
    Yang, Xuan
    Hu, Jiaoyang
    Ruan, Xin
    Mu, Fansong
    Fu, Yujie
    CURRENT ORGANIC CHEMISTRY, 2017, 21 (06) : 489 - 502
  • [49] Mutagenicity of coenzyme Q10
    Ikeda, K
    Suzuki, Y
    Yoshimura, I
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 2005, 51 (01) : 45 - 47
  • [50] Coenzyme Q10 effect on semen parameters: Profound or meagre?
    Vishvkarma, Rahul
    Alahmar, Ahmed T.
    Gupta, Gopal
    Rajender, Singh
    ANDROLOGIA, 2020, 52 (06)