NKT Cells Co-Expressing a GD2-Specific Chimeric Antigen Receptor and IL-15 Show Enhancedin Vivopersistence and Antitumor Activity Against Neuroblastoma

被引：0
|
作者：
Xu, Xin [1 ]
Huang, Wei [1 ]
Heczey, Andras [2 ]
Liu, Daofeng [1 ]
Guo, Linjie [1 ]
Wood, Micheal [1 ]
Jin, Jinglin [1 ]
Courtney, Amy [1 ]
Liu, Bin [1 ]
DiPiero, Erica [1 ]
Hicks, John [1 ]
Barragan, Gabriel [1 ]
Savoldo, Barbara [3 ]
Dotti, Gianpietro [3 ]
Metelitsa, Leonid [1 ]
机构：
[1] Baylor Coll Med, Houston, TX 77030 USA
[2] Baylor Coll Med, Sect Hematol & Oncol, Pediat, Houston, TX 77030 USA
[3] Univ N Carolina, Chapel Hill, NC 27515 USA
来源：
MOLECULAR THERAPY | 2019年 / 27卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
367
引用
收藏
页码：174 / 174
页数：1
相关论文
共 50 条
  • [21] CD19-CAR NK CELLS CO-EXPRESSING IL15/IL15Rα SHOW ENHANCED CYTOTOXICITY AGAINST B-CELL LEUKEMIA
    Silvestre, R. N.
    Eitler, J.
    de Azevedo, J. T. Teixeira Cottas
    Tonn, T.
    Picanco-Castro, V.
    CYTOTHERAPY, 2022, 24 (05) : S39 - S40
  • [22] Virus-free CRISPR knockin of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells
    Shankar, Keerthana
    Zingler-Hoslet, Isabelle
    Tabima, Diana M.
    Zima, Seth
    Shi, Lei
    Gimse, Kirstan
    Forsberg, Matthew H.
    Katta, Varun
    Davis, Sage Z.
    Maldonado, Daniel
    Russell, Brittany E.
    Murtaza, Muhammed
    Tsai, Shengdar Q.
    Ayuso, Jose M.
    Capitini, Christian M.
    Saha, Krishanu
    MOLECULAR THERAPY, 2025, 33 (03) : 1014 - 1030
  • [23] Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma
    Shen, Chan-Juan
    Yang, Yu-Xiu
    Han, Ethan Q.
    Cao, Na
    Wang, Yun-Fei
    Wang, Yi
    Zhao, Ying-Ying
    Zhao, Li-Ming
    Cui, Jian
    Gupta, Puja
    Wong, Albert J.
    Han, Shuang-Yin
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2013, 6
  • [24] Natural Killer T Cells Expressing a GD2-CAR and IL-15 for Children with Neuroblastoma - A First-In-Human Phase 1 Trial
    Heczey, Andras
    Courtney, Amy
    Robinson, Simon
    Liu, Ka
    Ghatwai, Nisha
    Savoldo, Barbara
    Dotti, Gianpietro
    Metelitsa, Leonid
    MOLECULAR THERAPY, 2020, 28 (04) : 555 - 555
  • [25] Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma
    Chan-Juan Shen
    Yu-Xiu Yang
    Ethan Q Han
    Na Cao
    Yun-Fei Wang
    Yi Wang
    Ying-Ying Zhao
    Li-Ming Zhao
    Jian Cui
    Puja Gupta
    Albert J Wong
    Shuang-Yin Han
    Journal of Hematology & Oncology, 6
  • [26] Combining ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cells with IL-15 Superagonist (N-803/ALT-803) to Target Chemotherapy Resistant Neuroblastoma
    Nayyar, Gaurav
    Chu, Yaya
    Negron, Olivia
    Lyngdoh, Jeremy
    Jeng, Emily K.
    Alter, Sarah
    Rhode, Peter R.
    Lee, John H.
    Ayello, Janet
    Lee, Dean
    Wong, Hing C.
    Cairo, Mitchell S.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (03)
  • [27] IL-15 Augments in-Vitro Expansion and Functional Activity of Antigen-Specific Effector Memory T-Cells (TEM) While Co-Expression of IL-15 and IL-15 Rα on Antigen Presenting Cells Also Promotes Expansion of Central Memory T-Cells (TCM)
    Hasan, Aisha
    Selvakumar, Annamalai
    Dupont, Bo
    Sadelain, Michel
    Riviere, Isabelle
    O'Reilly, Richard J.
    BLOOD, 2008, 112 (11) : 1213 - 1213
  • [28] A promising approach of GD2-specific chimeric antigen receptor (CAR) T cells with CD28/4.1BB costimulatory domains for treatment of GD2+sarcomas
    De Angelis, B.
    Camera, A.
    Orlando, D.
    Guercio, M.
    Sinibaldi, M.
    Cembrola, B. M.
    Caruso, S.
    Abbaszadeh, Z.
    Bovetti, K.
    Milano, G. M.
    Russo, I.
    De Vito, R.
    Quintarelli, C.
    Locatelli, F.
    HUMAN GENE THERAPY, 2019, 30 (11) : A69 - A70
  • [29] PiggyBac-engineered T cells expressing a glypican-3-specific chimeric antigen receptor show potent activities against hepatocellular carcinoma
    Wang, Pei
    Qin, Wenxia
    Liu, Tao
    Jiang, Duqing
    Cui, Lianzhen
    Liu, Xiangzhen
    Fang, Yuan
    Tang, Xi
    Jin, Huajun
    Qian, Qijun
    IMMUNOBIOLOGY, 2020, 225 (01)
  • [30] CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival
    Nie, Siyue
    Song, Yujie
    Hu, Kun
    Zu, Wei
    Zhang, Fengjiao
    Chen, Lixia
    Ma, Qiang
    Zhou, Zishan
    Jiao, Shunchang
    ONCOIMMUNOLOGY, 2024, 13 (01):
12345