Expression of Costimulatory Molecule B7-H4 in Human Malignant Tumors

被引：10
|
作者：
Zheng, Xiao [1 ]
Li, Xiao-Dong [1 ]
Wu, Chang-Ping [1 ]
Lu, Bin-Feng [2 ]
Jiang, Jing-Ting [1 ]
机构：
[1] Soochow Univ, Dept Tumor Biol Treatment, Affiliated Hosp 3, Changzhou 213003, Peoples R China
[2] Univ Pittsburgh, Dept Immunol, Sch Med, Pittsburgh, PA 15260 USA
来源：
ONKOLOGIE | 2012年 / 35卷 / 11期
关键词：
B7-H4; Costimulatory signal; Malignant tumor; Immune invasion; Molecular target; HUMAN OVARIAN-CARCINOMA; REGULATORY T-CELLS; LUNG-CANCER; B7; FAMILY; OVEREXPRESSION; SURVIVAL; IMMUNITY; PROTEIN; BREAST;
D O I：
10.1159/000343638
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
引用
收藏
页码：700 / 705
页数：6
相关论文
共 50 条
  • [21] Expression of B7-H3 and B7-H4 in experimental autoimmune encephalomyelitis
    Bando, Yoshio
    Zhu, Bing
    Chitinis, Tanuja
    Yoshida, Shigetaka
    Khoury, Samia
    NEUROSCIENCE RESEARCH, 2008, 61 : S109 - S109
  • [22] B7-H4 expression in various tumors determined using a novel developed monoclonal antibody
    Yun Qian
    Ling Shen
    Linfang Cheng
    Zhigang Wu
    Hangping Yao
    Clinical and Experimental Medicine, 2011, 11 : 163 - 170
  • [23] Roles of immune inhibitory molecule B7-H4 in cervical cancer
    Han, Sai
    Li, Yi
    Zhang, Jingjing
    Liu, Lu
    Chen, Qian
    Qian, Qiuhong
    Li, Shan
    Zhang, Youzhong
    ONCOLOGY REPORTS, 2017, 37 (04) : 2308 - 2316
  • [24] Prognostic significance of B7-H4 expression in pancreatic cancer
    Qian, Y.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 97 - 97
  • [25] Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
    Martin Loos
    Dennis M Hedderich
    Malte Ottenhausen
    Nathalia A Giese
    Melanie Laschinger
    Irene Esposito
    Jörg Kleeff
    Helmut Friess
    BMC Cancer, 9
  • [26] Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
    Loos, Martin
    Hedderich, Dennis M.
    Ottenhausen, Malte
    Giese, Nathalia A.
    Laschinger, Melanie
    Esposito, Irene
    Kleeff, Joerg
    Friess, Helmut
    BMC CANCER, 2009, 9
  • [27] B7-H4 expression in human infiltrating ductal carcinoma-associated macrophages
    Liu, Lei
    Li, Dalin
    Chen, Shuang
    Zhao, Ran
    Pang, Da
    Li, Dianjun
    Fu, Zhenkun
    MOLECULAR MEDICINE REPORTS, 2016, 14 (03) : 2135 - 2142
  • [28] Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia
    Hu, Yixin
    Lv, Xin
    Wu, Yujie
    Xu, Ji
    Wang, Lingling
    Chen, Weifeng
    Zhang, Wei
    Li, Jianyong
    Zhang, Sujiang
    Qiu, Hongxia
    Hematology, 2015, 20 (04) : 187 - 195
  • [29] Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer
    Byers, Joshua T.
    Paniccia, Alessandro
    Kaplan, Jeffrey
    Koenig, Michelle
    Kahn, Nate
    Wilson, Lora
    Chen, Lieping
    Schulick, Richard D.
    Edil, Barish H.
    Zhu, Yuwen
    ANNALS OF SURGICAL ONCOLOGY, 2015, 22 : S1574 - S1579
  • [30] B7-H4 Expression Promotes Tumorigenesis in Ovarian Cancer
    Cheng, Lei
    Jiang, Jie
    Gao, Ran
    Wei, Shuangyan
    Nan, Fangfang
    Li, Shaoru
    Kong, Beihua
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2009, 19 (09) : 1481 - 1486
12345