Effects of chromosome 9 inversion on IVF/ICSI: A 7-year retrospective cohort study

被引:8
|
作者
Liang, Shanshan [1 ]
Yang, Jianzhi [1 ]
Wu, Haixia [1 ]
Teng, Xiaoming [1 ]
Duan, Tao [1 ]
机构
[1] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Shanghai, Peoples R China
来源
MOLECULAR GENETICS & GENOMIC MEDICINE | 2019年 / 7卷 / 09期
关键词
gender; IVF; ICSI outcomes; karyotype; pericentric inversion of chromosome 9; PERICENTRIC-INVERSION; POLYMORPHISMS; FERTILIZATION; LOCUS; GENE;
D O I
10.1002/mgg3.856
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background This study focused on the outcomes of patients with pericentric inversion of chromosome 9 who underwent IVF/ICSI and fresh day 2 or day 3 embryo transfer and the possible impacts of carrier gender and chromosome karyotype on pregnancy outcomes. Methods A total of 214 couples (107 couples with one pericentric inversion of chromosome 9 in one partner [Group 1], 107 couples with normal karyotypes [Group 2]) underwent their first IVF/ICSI treatment and were included in this study. Oocyte number, normal fertilization rates, abnormal fertilization rates, cleavage rates, embryo utilization rates, fresh embryo transfer rates, clinical pregnancy rates (CPR), implantation rates, miscarriage rates, and live birth rates per embryo transfer (LBR) were compared between groups. Results Group 1 did not show any disadvantage when compared with Group 2. The CPR and LBR were similar between all groups. The female carrier group had a higher normal fertilization rate and higher utilization rate than the male carrier group. Cases with inv(9)(p12;q13) had a lower utilization rate but a higher implantation rate than the remaining karyotypes. Conclusion In the first IVF or ICSI cycle, couples with one pericentric inversion of chromosome 9 in one partner had satisfactory outcomes. The subgroup analysis showed a tendency of better prognosis for the female carrier and inv(9)(p12;q13) type.
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页数:8
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