A sesquiterpene glycoside and phenylalanine derivatives from Tinospora sinensis

被引：10
|
作者：
Huang, Liping [1 ]
Luo, Dezhi [1 ]
Fu, Rongrong [2 ]
Yan, Bo [1 ]
Wang, Xiaobing [3 ]
Shu, Jicheng [2 ]
Deng, Jiao [1 ]
Huang, Huilian [2 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
[3] China Pharmaceut Univ, State Key Lab Nat Med, Dept Nat Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
FITOTERAPIA | 2019年 / 137卷
基金：
中国国家自然科学基金;
关键词：
Tinospora sinensis; Sesquiterpene glycoside; Amide;
D O I：
10.1016/j.fitote.2019.104247
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new sesquiterpene glycoside and a new amide have been isolated from the stems of Tinospora sinensis. Their structures were established by 2D NMR spectroscopic techniques (H-1,H-1-COSY, NOESY, HSQC and HMBC) and mass spectrometry. The isolated compounds were subjected to evaluate neuroprotective activities in vitro. The pre-treatment of two new compounds can significantly ameliorate damage of oxidative stress induced by A beta(25-35) and improve PC12 cells survival.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] A new dinorclerone diterpenoid glycoside from Tinospora sinensis
    Dong, Lang-Ping
    Chen, Chang-Xiang
    Ni, Wei
    Xie, Bai-Bo
    Li, Jun-Zhu
    Liu, Hai-Yang
    NATURAL PRODUCT RESEARCH, 2010, 24 (01) : 13 - 17
  • [2] Structure and absolute configuration of clerodane diterpene glycosides and a rearranged cadinane sesquiterpene glycoside from the stems of Tinospora sinensis
    Li, Wei
    Wei, Kun
    Fu, Hongwei
    Koike, Kazuo
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (12): : 1971 - 1976
  • [3] Tinocordiside, a new rearranged cadinane sesquiterpene glycoside from Tinospora cordifolia
    Ghosal, S
    Vishwakarma, RA
    JOURNAL OF NATURAL PRODUCTS, 1997, 60 (08): : 839 - 841
  • [4] A sesquiterpene glucoside from Tinospora cordifolia
    Maurya, R
    Dhar, KL
    Handa, SS
    PHYTOCHEMISTRY, 1997, 44 (04) : 749 - 750
  • [5] Tinocordifolin, a sesquiterpene from Tinospora cordifolia
    Maurya, R
    Handa, SS
    PHYTOCHEMISTRY, 1998, 49 (05) : 1343 - 1345
  • [6] ANTILEISHMANIAL AGENTS FROM TINOSPORA SINENSIS
    Chand, Kailash
    Akanksha
    Singh, Nasib
    Dube, Anuradha
    Maurya, Rakesh
    MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S74 - S75
  • [7] Clerodane furanoditerpenoids from the stems of Tinospora sinensis
    Jun-Sheng Zhang
    De-Feng Xu
    Yin-Yin Wang
    Ren-Fen Ma
    Hua Zhang
    Archives of Pharmacal Research, 2022, 45 : 328 - 339
  • [8] Sesquiterpenes from Tinospora sinensis and their chemotaxonomic significance
    Ao, Rui
    Li, Ming-Hui
    Xiao, Zi-Nan
    Tang, Xue-Lian
    Zhang, Jun-Sheng
    Zhang, Hua
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2024, 116
  • [9] Lignans with NO inhibitory activity from Tinospora sinensis
    ZHANG Jun-Sheng
    XU De-Feng
    CAO Xin-Xin
    WANG Yin-Yin
    ZHANG Hua
    Chinese Journal of Natural Medicines, 2021, 19 (07) : 500 - 504
  • [10] Lignans with NO inhibitory activity from Tinospora sinensis
    Zhang Jun-Sheng
    Xu De-Feng
    Cao Xin-Xin
    Wang Yin-Yin
    Zhang Hua
    CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 19 (07) : 500 - 504
12345