Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats

被引：45

作者：

Abraham, WC ^{[1
]}

MasonParker, SE ^{[1
]}

Logan, B ^{[1
]}

机构：

[1] UNIV OTAGO,NEUROSCI RES CTR,DUNEDIN,NEW ZEALAND

来源：

BRAIN RESEARCH | 1996年 / 722卷 / 1-2期

关键词：

potentiation; long-term depression; seizure; hippocampus; synaptic plasticity;

D O I：

10.1016/0006-8993(96)00130-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ability of low-frequency stimulation (LFS) to induce either long-term depression (LTD) or depotentiation was assessed for perforant path synapses in the dentate gyrus of awake, adult rats. Neither LFS at 1 Hs (100 or 900 pulses) nor LFS at 3 Hz (900 pulses) was sufficient to produce either LTD or depotentiation. LFS at 3 Hz did produce a transient response depression of previously potentiated synapses, but this lasted less than 24 h and was secondary to seizure-like afterdischarges. We conclude that the LFS protocols so effective at eliciting LTD and depotentiation in area CA1 are ineffective for perforant path synapses in the dentate gyms.

引用

页码：217 / 221

页数：5

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