Serum Levels of Adiponectin and Ghrelin in Patients with Acute Myocardial Infarction

Background: Inflammation is widely known to play a key role in the development and progression of cardiovascular diseases. It has been observed that adipokines play an increasingly large role in systemic and local inflammation. Therefore, adipose tissue may have a more important role than previously thought in the pathogenesis of several disease types. We study serum levels of adiponectin and ghrelin in patients with acute myocardial infarction (AMI) with study of some of cardiovascular risk factors. Methods: We analyzed 64 patients with acute myocardial infarction admitted at our emergency unit and 20 age and sex matched healthy controls. Clinical parameters, glycemic, lipid profile, tumor necrosis factor-alpha (TNF-alpha), interleukin -6 (IL-6), serum insulin, insulin resistance (HOMA-IR), as well as serum adiponectin and ghrelin were assayed. Results: We found significantly (P < 0.01) increased levels of TNF-alpha, IL-6, insulin, and HOMA-IR in patients with AMI rather than healthy controls. Plasma adiponectin levels and ghrelin were significantly decreased (P < 0.01) compared to those of controls. We found significant correlations between plasma adiponectin levels and BMI, hypertension, TNF-alpha and IL-6. In the case of ghrelin, we found significant correlations with BMI, HDL-C, diabetes mellitus and fasting glucose. Conclusions: Low serum adiponectin and ghrelin level may be risk factor for AMI independent of other traditional cardiovascular risk factors and may provide a novel therapeutic target. [Elham O Hamed Nayel A Zaky and Amal K Norel Din. Serum Levels of Adiponectin and Ghrelin in Patients with Acute Myocardial Infarction. Life Sci J 2012; 9(2): 523-526]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 78