Square Planar Platinum(II) Complexes with N,S-Donor Ligands: Synthesis, Characterisation, DNA Interaction and Cytotoxic Activity

被引：7
|
作者：
Patel, Mohan N. [1 ]
Patel, Chintan R. [1 ]
Joshi, Hardik N. [1 ]
Vekariya, Pankaj A. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2014年 / 172卷 / 04期
关键词：
N; S-donor ligand; Platinum(II) complexes; DNA interaction; Unwinding; Cytotoxicity; IN-VITRO; BIOLOGICAL-ACTIVITY; ANTITUMOR-ACTIVITY; BINDING; PD(II); PT(II); CELLS; TRIS(PHENANTHROLINE)RUTHENIUM(II); CIS-DIAMMINEDICHLOROPLATINUM(II); RUTHENIUM(II);
D O I：
10.1007/s12010-013-0618-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The platinum(II) complexes with N,S-donor ligand have been synthesised and characterised by physiological techniques like elemental, electronic, Fourier transform infrared, hydrogen-1 nuclear magnetic resonance (H-1 NMR) and liquid chromatography-mass spectrometry spectra. The synthesised complexes have been checked for their DNA binding ability by absorption titration and viscosity measurement, and the results show that the complexes binds to herring sperm DNA (HS DNA) via covalent mode of binding. The DNA cleavage activity of synthesised complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA, showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Artemia cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesised complexes in terms of micromolars.
引用
收藏
页码：1846 / 1858
页数：13
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