Cyclohexanones by Rh-Mediated Intramolecular C-H Insertion

被引：27
|
作者：
Taber, Douglass F. [1 ]
Paquette, Craig M. [1 ]
Gu, Peiming [1 ]
Tian, Weiwei [1 ]
机构：
[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 19期
基金：
美国国家科学基金会;
关键词：
CARBON-HYDROGEN INSERTION; BETA-LACTAM ANTIBIOTICS; ENANTIOSELECTIVE SYNTHESIS; CYCLOPENTANE CONSTRUCTION; MOLECULAR COMPLEXITY; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; BOND ACTIVATION; DIAZO KETONES; DESIGN;
D O I：
10.1021/jo4014996
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some long chain alpha-aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to the corresponding cyclohexanones. This is in marked contrast to the cyclizations of alpha-diazo beta-ketoesters, which consistently deliver cyclopentanone products.
引用
收藏
页码：9772 / 9780
页数：9
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