Prevention of immunoglobulin E production as a therapeutic target

被引：1

作者：

Woisetschläger, M ^{[1
]}

Stütz, AM ^{[1
]}

Ettmayer, P ^{[1
]}

机构：

[1] Novartis Forschungsinst, Dept Allerg Dis, A-1230 Vienna, Austria

来源：

DRUG NEWS & PERSPECTIVES | 2002年 / 15卷 / 02期

关键词：

D O I：

10.1358/dnp.2002.15.2.704649

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immunoglobulin E (IgE) has been known for quite some years to be critically involved in the initiation of a number of allergic diseases. Its importance as therapeutic target was confirmed and strengthened by recent evidence that neutralizing monoclonal antibodies directed against IgE showed clinical efficacy in large clinical trials with patients suffering from asthma and allergic rhinitis. These data, for the first time, confirmed the predictions made from results obtained in numerous animal studies. This contribution discusses the importance of IgE as therapeutic target in allergic diseases with special emphasis on approaches aimed at inhibiting IgE synthesis by B-lymphocytes. (C) 2002 Prous Science. All rights reserved.

引用

页码：78 / 84

页数：7

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