The locus coeruleus mediates behavioral flexibility

被引:12
|
作者
McBurney-Lin, Jim [1 ,2 ]
Vargova, Greta [1 ]
Garad, Machhindra [1 ]
Zagha, Edward [2 ,3 ]
Yang, Hongdian [1 ,2 ]
机构
[1] Univ Calif Riverside, Dept Mol Cell & Syst Biol, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Neurosci Grad Program, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
来源
CELL REPORTS | 2022年 / 41卷 / 03期
基金
美国国家卫生研究院;
关键词
PREFRONTAL CORTEX; CERULEUS NEURONS; NORADRENERGIC SYSTEM; INTEGRATIVE THEORY; CORTICAL-NEURONS; NOREPINEPHRINE; MONKEY; ACTIVATION; MODULATION; ATTENTION;
D O I
10.1016/j.celrep.2022.111534
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Behavioral flexibility is the ability to adjust behavioral strategies in response to changing environmental con-tingencies. A major hypothesis in the field posits that the activity of neurons in the locus coeruleus (LC) plays an important role in mediating behavioral flexibility. To test this hypothesis, we developed a tactile-based rule-shift detection task in which mice responded to left and right whisker deflections in a context-dependent manner and exhibited varying degrees of switching behavior. Recording spiking activity from optogenetically tagged neurons in the LC at millisecond precision during task performance revealed a prominent graded cor-relation between baseline LC activity and behavioral flexibility, where higher baseline activity following a rule change was associated with faster behavioral switching to the new rule. Increasing baseline LC activity with optogenetic activation accelerated task switching and improved task performance. Overall, our study pro-vides important evidence to reveal the link between LC activity and behavioral flexibility.
引用
收藏
页数:13
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