Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines

被引:2
|
作者
Fallouh, Hanan [1 ]
Mahana, Wahib [2 ,3 ]
机构
[1] Univ Damascus, Fac Sci, Damascus, Syria
[2] Univ Bretagne Occidentale, F-91405 Orsay, France
[3] Univ Paris 11, IGM, UMR 86216, F-91405 Orsay, France
来源
TOXINS | 2012年 / 4卷 / 10期
关键词
HTLV-I; leukemogenesis; heat shock proteins; antibodies; animal model; HEAT-SHOCK PROTEINS; STRESS-RESPONSE; COGNATE PROTEIN; EXPRESSION; INDUCTION; KDA; AUTOIMMUNITY; ASSOCIATION; LYMPHOCYTES; REACTIVITY;
D O I
10.3390/toxins4100768
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Adult T cell leukemia is a fatal malignant transformation caused by the human T-cell lymphoptropic virus type I (HTLV-I). HTLV-I is only associated with the development of this disease in a small percentage of infected individuals. Using two rabbit transformed T-cell lines; RH/K30 (asymptomatic) and RH/K34 (leukemogenic), we have investigated the expression of heat shock proteins (HSP) 90 and 70 and the role of anti-HSPs antibodies on virus production. HSPs surface expression was higher on RH/K34 than RH/K30 cells. Heat treatment of cells increased the expression of HSPs proteins and virus production; HSPs augmentation was stabilized after 12 h and virus production reached a maximum between 8 h-12 h then returned to normal level after 24 h of culture. Incubation of cells only with rabbit anti-HSP 70 antibodies prevented virus production specifically in the leukemogenic cell line. The results indicate a relationship between HSP 70 and virus production.
引用
收藏
页码:768 / 777
页数:10
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