An efficient synthesis of enantiomerically pure trans-N1,N2-dimethylcyclohexane-1,2-diamine

被引：2
|
作者：
Shen, Yan-Hong [1 ]
Ye, Qing [2 ]
Hou, Shao-Gang [1 ]
Wang, Qun [1 ]
机构：
[1] Anyang Inst Technol, Dept Chem Engn, Anyang 455000, Peoples R China
[2] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2013年 / 04期
关键词：
kinetic resolution; chirality; cyclohexene oxide; N-1,N-2-dimethylcyclohexane-1,2-diamine; ring-opening reactions; INHIBITORS; COMPLEXES;
D O I：
10.3184/174751913X13626731204890
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new pathway is described to produce a highly optically pure isomer of trans-N-1,N-2-dimethylcyclohexane-1,2-diamine through four simple steps. Reaction of cyclohexene oxide with aqueous methylamine, followed by cyclisation with Mitsunobu reagent and ring-opening reactions gave rac-trans-N-1,N-2-dimethylcyclohexane-1,2-diamine, and the enantiomers were obtained via a kinetic resolution using tartaric acid.
引用
收藏
页码：191 / 192
页数：2
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