Facile one-pot synthesis of ethyl 3-alkyl-4-hydroxy-2-thioxothiazoildine-4-carboxylates

被引：5

作者：

Ge, ZM ^{[1
]}

Li, Q ^{[1
]}

Zheng, SJ ^{[1
]}

Cheng, TM ^{[1
]}

Cui, YX ^{[1
]}

Li, RT ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2006年 / 24卷 / 03期

关键词：

ethyl; 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylate; primary amine; 3-bromo-2-oxopropanoate; one-pot synthesis; anhydrous potassium phosphate;

D O I：

10.1002/cjoc.200690073

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3-bromo-2-oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically JR, H-1 NMR, C-13 NMR, EI-MS) and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.

引用

页码：381 / 385

页数：5

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