A convergent approach to cyclopeptide alkaloids: Total synthesis of Sanjoinine G1

被引：63

作者：

Temal-Laib, T ^{[1
]}

Chastanet, J ^{[1
]}

Zhu, JP ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 04期

关键词：

D O I：

10.1021/ja0170807

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general strategy for the synthesis of cyclopeptide alkaloids containing an endocyclic arylalkyl ether bond has been developed featuring a key intramolecular SNAr reaction. The importance of the N-terminal protective group in the realization of such a strategy is documented. From the appropriate amino acid constituents, the natural sanjoinine G1, a 14-membered para cyclophane, has been synthesized in seven steps with 21% overall yield.

引用

页码：583 / 590

页数：8

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