Fhit protein expression in human gastric cancer and related precancerous lesions

被引：3
|
作者：
Caselli, M
Marchisio, M
Gaudio, M
Saragoni, L
Lanza, G
Alvisi, V
Bertagnolo, V
Concu, M
Capitani, S
Caramelli, E
机构：
[1] Univ Ferrara, Human Anat Branch, Dept Morphol & Embryol, I-44100 Ferrara, Italy
[2] Univ Ferrara, Inst Internal Med 1, I-44100 Ferrara, Italy
[3] Morgagni Pierantoni Hosp, Dept Pathol, Forli, Italy
[4] Univ Ferrara, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy
[5] Univ Bologna, Inst Histol & Gen Embryol, I-40126 Bologna, Italy
来源：
ONCOLOGY REPORTS | 2001年 / 8卷 / 06期
关键词：
gastric carcinogenesis; FHIT; RT-PCR; Fhit protein immunostaining;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The FHIT gene is altered in several types of tumors and abnormal expression of Fhit protein have also been reported in some preneoplastic lesions. We have determined the Fhit expression on histological samples of 26 patients affected by preneoplastic lesions who developed a gastric cancer within 2 years. The expression of the Fhit protein was always present in all preneoplastic lesions, while the Fhit protein immunostaining was distributed unevenly in 10 cases and completely lost in 6. The complete loss of Fhit expression only in areas of neoplastic low differentiation suggests that FHIT gene takes part in late gastric carcinogenesis.
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页码：1233 / 1237
页数：5
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