Effects of Patient-Driven Lifestyle Modification Using Intermittently Scanned Continuous Glucose Monitoring in Patients With Type 2 Diabetes: Results From the Randomized Open-label PDF Study

被引:20
|
作者
Choe, Hun Jee [1 ,2 ]
Rhee, Eun-Jung [3 ]
Won, Jong Chul [4 ]
Park, Kyong Soo [1 ,2 ]
Lee, Won-Young [3 ]
Cho, Young Min [1 ,2 ]
机构
[1] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea
[2] Seoul Natl Univ Hosp, Div Endocrinol & Metab, Dept Internal Med, Seoul, South Korea
[3] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Endocrinol & Metab, Dept Internal Med,Sch Med, Seoul, South Korea
[4] Inje Univ, Sanggye Paik Hosp, Div Endocrinol & Metab, Dept Internal Med, Seoul, South Korea
关键词
SENSING TECHNOLOGY; REAL-TIME; NUTRITION; RECOMMENDATIONS; MULTICENTER; MANAGEMENT; ADULTS; CARE;
D O I
10.2337/dc22-0764
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To investigate the effects of patient-driven lifestyle modification using intermittently scanned continuous glucose monitoring (isCGM) in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a 12-week, open-label, randomized controlled trial. A total of 126 participants were 1:1 randomized to either the intervention group (structured education + isCGM) or the control group (standard care with blood glucose monitoring). The Self-Evaluation Of Unhealthy foods by Looking at postprandial glucose (SEOUL) algorithm was developed and applied to aid structured education in guiding patients to follow healthy eating behavior depending on the postprandial glycemic response. The primary end point was the change in HbA(1c) level from baseline. RESULTS Implementation of the SEOUL algorithm with isCGM was associated with greater improvement in HbA(1c) than with standard care (risk-adjusted difference -0.50%, 95% CI -0.74 to -0.26, P < 0.001). Participants in the intervention group had a greater reduction in fasting blood glucose and body weight (-16.5 mg/dL, 95% CI -30.0 to -3.0, P = 0.017; -1.5 kg, 95% CI -2.7 to -0.3, P = 0.013, respectively). The score sum for the Korean version of the revised Summary of Diabetes Self-Care Activities Questionnaire increased in both groups but to a greater extent in the intervention group (mean difference 4.8, 95% CI 1.7-8.0, P = 0.003). No severe hyperglycemia or hypoglycemia was reported in either group of patients. CONCLUSIONS Patient-driven lifestyle modification primarily focused on eating behavior using isCGM effectively lowered HbA(1c) levels in patients with T2D.
引用
收藏
页码:2224 / 2230
页数:7
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