Targeted cancer immunotherapy Mimicking physiological trans-presentation of IL-15

被引：3
|
作者：
Mueller, Dafne [1 ]
机构：
[1] Univ Stuttgart, Inst Zellbiol & Immunol, D-70174 Stuttgart, Germany
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 07期
关键词：
IL-15; IL-15R alpha; antibody fusion protein; targeting; trans-presentation; T-CELLS; INTERLEUKIN-15; TUMORS; NK;
D O I：
10.4161/onci.20824
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Under physiological conditions, the trans-presentation of interleukin-15 (IL-15) by the IL-15 receptor alpha on the cell surface allows to confine and tune the IL-15-mediated immune responses. Therefore, targeting strategies that mimic this situation at the tumor sites appear especially promising for anticancer immunotherapy.
引用
收藏
页码：1213 / 1214
页数：2
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