Safety and efficacy of an extended-regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol

被引：75
|
作者：
Anderson, FD [1 ]
Gibbons, W
Portman, D
机构：
[1] Eastern Virginia Med Sch, Jones Inst Reprod Med, Norfolk, VA 23507 USA
[2] Columbus Ctr Womens Hlth Res, Columbus, OH 43213 USA
来源：
CONTRACEPTION | 2006年 / 73卷 / 03期
关键词：
Seasonique (TM); extended regimen; oral contraceptive; ethinyl estradiol; pregnancy;
D O I：
10.1016/j.contraception.2005.09.010
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To assess the efficacy and safety of Seasonique (TM), a 91-day extended-regimen oral contraceptive (OC) utilizing continuous low-dose ethinyl estradiol (EE) during the typical hormone-free interval. Methods: A multicenter, open-label, 1-year study of Seasonique (TM) [30 mu g EE/150 mu g levonorgestrel (LNG)] for 84 days followed by EE 10 mu g for 7 days was conducted in sexually active, adult women of childbearing potential. All patients completed daily electronic diaries to monitor compliance and bleeding. Results: Method failure rate was 0.78 (Pearl index) and 0.64% (life table analysis). Cycle control and safety of the regimen were similar to that reported for other OCs. Conclusion: This study demonstrates that Seasonique (TM) is effective, safe and well tolerated for the prevention of pregnancy. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：229 / 234
页数：6
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