Merkel Cell Carcinoma

被引:34
|
作者
Ramahi, Emma [1 ]
Choi, Jehee [1 ]
Fuller, Clifton D. [1 ,2 ]
Eng, Tony Y. [1 ,2 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiat Oncol, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Human Imaging Program, Div Radiol Sci, Dept Radiol, San Antonio, TX 78229 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2013年 / 36卷 / 03期
基金
美国国家卫生研究院;
关键词
Merkel cell carcinoma; etiology; imaging; surgery; radiation therapy; chemotherapy; POSITRON-EMISSION-TOMOGRAPHY; MOHS MICROGRAPHIC SURGERY; LYMPH-NODE BIOPSY; RADIATION-THERAPY; TRABECULAR CARCINOMA; LOCOREGIONAL CONTROL; CASE SERIES; POLYOMAVIRUS; SKIN; MANAGEMENT;
D O I
10.1097/COC.0b013e318210f83c
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors. Other suggested risk factors include sun exposure, immunosuppression, and a history of prior malignancy. Work up of patients with MCC most notably includes nodal staging via clinical examination or sentinel lymph node biopsy. The prognosis for most patients with MCC is poor, and the rarity of MCC precludes the prospective, randomized clinical trials necessary to elucidate optimum treatment protocols. Most published data support the use of a multimodality approach centered around surgical excision with negative margins, sentinel lymph node biopsy to establish the presence or absence of nodal metastases, adjuvant radiothearpy to decrease the risk of recurrence, and systemic chemotherapy in the case of widespread disease.
引用
收藏
页码:299 / 309
页数:11
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