Cognitive behavioral psychotherapy (CBT) is one of the first choices for the treatment of depression in adolescents but to date no German treatment program has been evaluated in a randomized controlled trial. The study comprised 38 depressed adolescents (M = 15.86; SD = +/- 1.70 years old; 78.9% girls) whowere randomly assigned to a control group (CG), a group that received treatment as usual (TAU), or an intervention group (IG) that participated in a brief outpatient group CBT called MICHI. To determine treatment efficacy, changes in the CDRS-R and BDI-II scores before and after TAU or CBT were collected and compared between groups. The interaction effects, of groups and time points, were significant (p = .02) for the CDRS-R, with a moderate effect size (d(korr) = .75), and for the BDI-II (p = .04), with a small effect size (d(korr) = .39). The results of the present study reveal that a brief CBT, in a group format, was significantly more effective than TAU.