Synthesis of 4′-substituted-2,2′;6′,2"-terpyridine Ru(II) complexes electrochemical, fluorescence quenching and antibacterial studies

被引：23
|
作者：
Ezhilarasu, Tamilarasu [1 ]
Sathiyaseelan, Anbazhagan [2 ]
Kalaichelvan, Pudupalayam Thangavelu [2 ]
Balasubramanian, Sengottuvelan [1 ]
机构：
[1] Univ Madras, Dept Inorgan Chem, Guindy Campus, Madras 600025, Tamil Nadu, India
[2] Univ Madras, CAS Bot, Guindy Campus, Madras 600025, Tamil Nadu, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2017年 / 1134卷
关键词：
Terpyridine; Ruthenium(II) complex; Spectral study; Thermal study; Cyclic voltammetry; Antibacterial activity; CELL-CYCLE ARREST; METAL-COMPLEXES; BUILDING-BLOCKS; DNA-INTERACTION; RUTHENIUM; TRANSITION; BINDING; INTERCALATORS; CYTOTOXICITY; PHOTOPHYSICS;
D O I：
10.1016/j.molstruc.2016.12.102
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Three new Ru(II) terpyridine complexes viz. [Ru(BBtpy)(2)](PF6)(2) [Ru(L1)] (BBtpy = 4'-(4benzyloxybenzaldehyde)-2,2':6',2 ''-terpyridine), [Ru(BMBtpy)(2)](PF6)(2) [Ru(L2)] (BMBtpy = 4'-(4benzyloxy-3-methoxybenzaldehyde)-2,2':6',2"-terpyridine) and [Ru(BEBtpY)(2)](PF6)(2) [Ru(L3)] (BEBtpy = 4'-(4-benzyloxy-3-ethoxybenzaldehyde)-2,2':6',2 ''-terpyridine) have been synthesized and characterized. The MALDI-TOF/MS fragmentation pattern of [Ru(BMBtpy)2](PF6)2 complex exhibits a molecular ion peak at m/z = 987.09 [M-2PF(6)](2+) fragment. These Ru(II) complexes are redox active, show both metal centered oxidation and ligand centered reduction processes. The peak potential and peak current I-pa and I-PC also undergo definite shift and increase with increase in the scan rate (20-120 mV/s). The fluorescence of Ru(II) complexes [Ru(L1)], [Ru(L2)] and [Ru(L3)] are effectively quenched by 1,4benzoquinone and 1,4-naphthoquinone in acetonitrile. The antibacterial activity of ruthenium(II) complexes were screened against four human pathogens both gram -positive bacteria (Bacillus subtilis, Staphylococcus aureus) and gram negative bacteria (Escherichia coli, Klebsiella pneumonia) by the well diffusion method. The antibacterial activity of Ru(II) complexes is comparable to that of standard antibiotics like tetracycline. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：265 / 277
页数：13
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